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Prednisone & Weight Gain (The Studies) Many studies have been conducted to evaluate the side effect profile of prednisone and similar corticosteroid medicationsat different doses. One of the studies showed that prednisone may lead to weight gain in rats fed an overfeeding regime including a high-carb diet. A further study looked at the effect of prednisone on weight in rats and rats maintained on a high-fat diet, and found that a dose of prednisone comparable to the typical human administration is capable of influencing bodyweight. As this is a rodent study it is difficult to conclude any conclusions about human obesity, but the data are encouraging. [8] Other weight gain effects: There is another study in obese humans. The authors measured the food intake of over 80 overweight and obese patients at baseline and 12 weeks, and they found that weight gain was not associated with changes in their prednisone dosage or weight loss. They also found no significant difference between prednisone doses that had been used in the original study and those that had not been used in that study. [9] Prednisone Dosage Prednisone is a glucuronide hormone that affects body fat and blood calcium levels. The human dose of prednisone is one hour of a 3.2 mg/kg IM dose every four hours. There is a common assumption that you don't need high doses of glucuronides to influence blood calcium levels, which is true, but the body uses the glucuronide as a precursor to an important precursor to calcium, osteocalcin, to maintain blood calcium levels. In turn, osteocalcin causes fat gain over time, and thus the use of very high doses of glucuronides seems to be more detrimental to weight control than low doses. This is not to say high-dose glucuronides won't induce significant weight gain—on the contrary, they can have profound effects on fat gains and fat distribution. The reason is that higher glucuronide doses are associated with more rapid calcium absorption and, in turn, increased bone mass in the long term. In rodents, this happens when rats are given a high-dose glucuronide dose. Rats with bone loss show a higher rate of growth and increased total body fat as well as body weight. This may be an important mechanism with prednisone users who are at risk for osteoporosis because high calcium intakes, a large percentage of which come through bone loss, are associated with the onset of osteoporosis. [10] The recommended maximum dietary dose of prednisone is 3 mg/kg every four hours. This is also the dose Related Article:

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Anadrol 250 mg, buy real growth hormone

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